Abstract: IMPORTANCE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are considered safe, effective medications for type 2 diabetes (T2D) and weight loss, used by millions …
Abstract: BACKGROUND: Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for …
Abstract: Precision healthcare aims to tailor disease prevention and early detection to individual risk. Prostate cancer screening may benefit from genomics-informed approaches. We …
Abstract: Background: Black individuals have higher incidence and mortality rates of prostate cancer than White individuals, and existing literature on treatment sequencing …
Abstract: Previous studies have demonstrated a higher prevalence of keratinocyte carcinomas (KC) on sunâexposed areas, particularly for squamous cell carcinoma (SCC) compared to …
Abstract:Hereditary transthyretin amyloidosis is caused by pathogenic variants in the TTR gene, resulting in abnormal TTR (transthyretin) that deposits in organs. The c.424G>A …
Abstract: This cross-sectional study evaluates trends in the utilization of and disparities in prostate magnetic resonance imaging (MRI) across the Veterans Health Administration.
Abstract:Objective: The prevalence of moderate to severe asymptomatic carotid stenosis (i.e., atherosclerotic narrowing of the extracranial carotid arteries) is generally âź6% and …
Abstract: IMPORTANCE: Pharmacogenetics can improve medication-related outcomes by optimizing efficacy and minimizing adverse effects. It is unknown whether the presence of …
Abstract: CYP2C19 loss-of-function (LOF) alleles decrease the antiplatelet effect of clopidogrel following percutaneous coronary intervention (PCI) in patients presenting with …
Abstract: Given the various roles of testosterone in menâs health, we conducted a multi-ancestral genetic analysis of total testosterone, free testosterone, SHBG, and …
Abstract: Purpose: This study introduces an integrated approach using structured and unstructured data from an electronic health record to identify and characterize patient …