• Author: Mark W. Logue
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Machine learning-based risk scores are associated with conversion to dementia in Veterans

Abstract: Background: We previously developed ancestry-specific risk scores for undiagnosed Alzheimer's disease and related dementias (ADRD) in Black and White American (BA and WA) …

Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD

Abstract: Glial fibrillary acidic protein (GFAP) is an astrocytic marker that can be assessed in blood using single molecule array technology. Recent studies suggest that …

Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β(42:40) in Veterans

Abstract: BackgroundIdentifying biomarkers of Alzheimer's disease (AD) is critical for early diagnosis and AD risk assessment.ObjectiveWe examined the hypothesis that the plasma …

Curation and validation of electronic medical record-based dementia diagnoses in the Veterans Affairs Million Veteran Program

Abstract: Background: The age distribution and diversity of the VA Million Veteran Program (MVP) cohort make it a valuable resource for studying the genetics of Alzheimer's disease …

Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts

Abstract: Background: Incorporating genomic data into risk prediction has become an increasingly popular approach for rapid identification of individuals most at risk for complex …

Traumatic brain injury and genetic risk for Alzheimer's disease impact cerebrospinal fluid β-amyloid levels in Vietnam War Veterans

Abstract: Traumatic brain injuries (TBIs) may increase the risk for Alzheimer's disease (AD) and its neuropathological correlates, although the mechanisms of this relationship are …

Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older Veterans

Abstract: Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for …

Genome-wide association study of traumatic brain injury in US military veterans enrolled in the VA million veteran program

Abstract: Large-scale genetic studies of traumatic brain injury (TBI) are lacking; thus, our understanding of the influence of genetic factors on TBI risk and recovery is …