• Author: Melanie E. Garrett
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Whole exome sequencing analysis of suicidal thoughts and behaviors in a Veteran cohort implicates inflammatory pathways and genes previously associated with psychiatric and neurodegenerative diseases

Abstract: BACKGROUND: Suicide is a leading cause of death among younger veterans; however, the genetic basis of suicide remains largely unknown. While prior genome-wide association …

Accelerated epigenetic aging and prospective morbidity and mortality among U.S. Veterans

Abstract: BACKGROUND: Epigenetic aging measures have promise as surrogate health outcomes in randomized control trials and observational cohort studies. The value of these …

Accelerated biological aging and midlife frailty among U.S. military Veterans

Abstract: Injuries characterizing recent military service, such as traumatic brain injury and posttraumatic stress disorder, are linked to accelerated biological aging. If recent …

Deployment-Related Toxic Exposures Are Associated with Worsening Mental and Physical Health After Military Service: Results from a Self-Report Screening of Veterans Deployed After 9/11

Abstract: Exposure to toxins-such as heavy metals and air pollution-can result in poor health and wellbeing. Recent scientific and media attention has highlighted negative health …

Demographic Characteristics and Epigenetic Biological Aging Among Post-9/11 Veterans: Associations of DunedinPACE with Sex, Race, and Age

Abstract: Measures of epigenetic aging derived from DNA methylation (DNAm) have enabled the assessment of biological aging in new populations and cohorts. In the present study, we …

Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 Veterans

Abstract: People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is …

Genome-wide DNA methylation analysis of cannabis use disorder in a Veteran cohort enriched for posttraumatic stress disorder

Abstract: Cannabis use has been increasing over the past decade, not only in the general US population, but particularly among military veterans. With this rise in use has come a …

Impact of traumatic life events and polygenic risk scores for major depression and posttraumatic stress disorder on Iraq/Afghanistan Veterans

Abstract: Traumatic experiences and genetic heritability are among the most widely acknowledged risk factors leading to the development of psychopathology; including posttraumatic …