• Author: Sylvanus Toikumo
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Candidate genes from an FDA-approved algorithm fail to predict opioid use disorder risk in over 450,000 Veterans

Abstract: Importance: Recently, the Food and Drug Administration gave pre-marketing approval to algorithm based on its purported ability to identify genetic risk for opioid use …

A multi-ancestry genetic study of pain intensity in 598,339 Veterans

Abstract: Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes …

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Abstract: Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits, commonly co-occur in the general population. Single-trait genome-wide association …