Allopurinol and the risk of diabetic macular edema among U.S. Veterans with type 2 diabetes

Abstract: Background: By inhibiting xanthine oxidase, subsequent inflammatory cytokine release and the resulting breakdown of the blood-retina barrier, allopurinol may limit the …

Design and Rationale for the Veterans Affairs “Cooperative Study Program 594 Comparative Effectiveness in Gout : Allopurinol vs. Febuxostat” Trial

Abstract: Background: Gout patients do not routinely achieve optimal outcomes related in part to suboptimal administration of urate lowering therapy (ULT) including …