SOD2 genetics regulating mitochondrial management of oxidative stress is tied to chemical sensitivity in Gulf War Veterans

Abstract: Multiple chemical sensitivity (MCS), though viewed by many as psychogenic, was presumptively tied to genetic variation in superoxide dismutase 2 (SOD2), involved in …

The Veterans Affairs Million Veteran Program, Alzheimer's disease, and genetics: Important steps forward but many steps still to go on the march to control dementia and Alzheimer's disease

Abstract: The VA Million Veteran Program (MVP) is a nationwide initiative that seeks to examine how genes influence health and behaviors in military veterans. An article by Merritt …

Design and pilot results from Million Veteran Program return of actionable genetic results (MVP-ROAR) study

Abstract: Background: As a mega-biobank linked to a national healthcare system, the Million Veteran Program (MVP) can directly improve the health care of participants. To determine …

Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type two diabetes: The Veterans Affairs Diabetes Trial

Abstract: Background: Intensive glycemic control reduced the risk of coronary artery disease (CAD) events among White ACCORD study participants with the haptoglobin (Hp)2-2 …

Candidate genes from an FDA-approved algorithm fail to predict opioid use disorder risk in over 450,000 Veterans

Abstract: Importance: Recently, the Food and Drug Administration gave pre-marketing approval to algorithm based on its purported ability to identify genetic risk for opioid use …

Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk

Abstract: BACKGROUND: Suicide is a leading cause of death worldwide. Whereas some studies have suggested that a direct measure of common genetic liability for suicide attempts …

Uncommon protein-coding variants associated with suicide attempt in a diverse sample of US Army soldiers

Abstract: BACKGROUND: Suicide is a societal and public health concern of global scale. Identifying genetic risk factors for suicide attempt can characterize underlying biology and …

Genome-wide association study of traumatic brain injury in US military veterans enrolled in the VA million veteran program

Abstract: Large-scale genetic studies of traumatic brain injury (TBI) are lacking; thus, our understanding of the influence of genetic factors on TBI risk and recovery is …

T1. genome-wide association study of the five-factor dysphoric arousal model of posttraumatic stress disorder in the million veteran program

Abstract: Background: We reported previously that a five-factor dysphoric arousal model (subdomains of re-experiencing, avoidance, numbing, dysphoric arousal, and anxious arousal) …

Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden

Abstract:Background: Little is known about environmental factors that may influence associations between genetic liability to suicidality and suicidal behavior. Methods: This study …

Fear reacquisition and symptoms of combat-related PTSD: Specificity and preliminary examination of the influence of the 5-HT3A receptor gene

Abstract: Several studies have examined the acquisition and extinction of fear in PTSD in the context of Pavlovian conditioning. However, research examining reconditioning of …

The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions

Abstract: United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health …