Evaluation of the reconsolidation of traumatic memories protocol for the treatment of PTSD: a randomized, wait-list-controlled trial

Abstract: Introduction: The reconsolidation of traumatic memories (RTM) is a cognitive intervention for post-traumatic stress disorder (PTSD) believed to employ reconsolidation blockade with significant potential as a cost-effective and empirically supported treatment. This is the second empirical evaluation of the intervention. Methods: This study used a randomized wait-list-controlled design (n=30) to examine the efficacy of three sessions of RTM among male Veterans having high symptom scores on the PTSD Symptom Scale Interview (PSS-I) and the PTSD Checklist – military version (PCL-M) with current-month flashbacks and nightmares. Of the 55 volunteers, 30 met inclusion criteria and participated in the study, 15 each were randomly assigned to treatment and control conditions. After completing a six-week wait period, control subjects also received the intervention. Results: Data analyses suggest that RTM was superior to control. There were significant pre-post treatment improvements across measures of PTSD. Gains were maintained at 6 and 12-month follow-ups. At six months post, within group RTM effect sizes (Hedges' g) ranged from 2.79 to 5.33. Further, at six months post, 88% of those treated had lost the DSM diagnosis for PTSD: 15% had lost DSM diagnosis (CPL-M<50 and DSM criteria not met) and 73% were in complete remission from all symptoms (PCL-M<30). Therapist competence and adherence to treatment protocols were both strong. Patient satisfaction with the intervention was high. Discussion: Study limitations and implications for the assessment and treatment of Veterans with PTSD are discussed.