Abstract: Objective: To determine the influence of years of military service and deployment era on neurocognitive performance. Method: Archival data included 316 veterans (89.6% male; 94.3% White) seen for neuropsychological evaluation at the Portland VA (M/SD: age = 55.54/14.39; education = 13.32/2.44). Participants were administered a comprehensive neuropsychological battery. Two-way between-subjects analyses of variance (ANOVAs) examined the effects of years of service and deployment era on test performance. Bonferroni post-hoc tests compared differences between groups when a significant main effect was observed. Results: Significant main effects were found for deployment era on TOMM Retention trial (F(4, 20) = 4.39, p = 0.04), WAIS-IV Block Design (F(5, 244) = 2.45, p = 0.04), WMS-IV Logical Memory I (F(5, 230) = 3.79, p < 0.01), Trail Making Test Part A (F(5, 242) = 3.54, p < 0.01), Trail Making Test Part B (F(5, 227) = 3.38, p < 0.01) and Grooved Pegboard for nondominant hand (F(4, 86) = 3.22, p < 0.05). Significant main effects were also observed for years of service for Trail Making Test Part A (F(4, 242) = 2.81, p < 0.05) and DKEFS Color-Word Trial 2 (F(4, 77) = 2.67, p < 0.05). A significant interaction was found between deployment era and years served on the BVMT-R total recall score (F(15, 213) = 1.92, p < 0.05). Post-hoc analyses did not reveal significant variance accounted for on neuropsychological tests. Conclusions: While there were significant differences between multiple measures, deployment era and years of service do not impact veteran’s cognitive performance.