Abstract: Background: Depression, a recently recognized cardiovascular disease (CVD) risk factor, is more common in women. US women Veterans (WV) are a growing and at high-risk population for CVD. Goals of this project were to 1) investigate trends in the prevalence of depression among the US WV from 2000 to 2019, assess potential race/ethnicity differences, and 2) compare the latest rates between US WV and US civilian women. Methods: National veterans affairs (VA) electronic medical records were used to identify all women who visited any VAs from 1/1/2000 to 12/31/2019. Results: The overall prevalence of depression among US WV increased from 4,826 (6.0%) to 289,446 (39.2%) during this period. While the increase was observed in all races and ethnic cohorts, it was most pronounced for Black and American Indian (AI) VW (48% and 47% prevalence in 2019, respectively). Alarmingly, the prevalence rates for different race/ethnicity cohorts diverged significantly over the past decade, impacting Blacks, AI, and Hispanics the most. Finally, the overall prevalence rate of 39.2% observed in 2019 for WV was significantly higher than the 23.4% reported by Center for Disease Control in 2020 for civilian women. Conclusion: Research is required to better understand the mechanisms underlying the depression-CVD association, and effective actionable interventions are required to improve the cardiovascular health for all women, especially WV.