Abstract: Background: Obesity, a cardiovascular disease (CVD) risk factor, has steadily increased in US over the past four decades. US women Veterans (WV) are a growing and at high-risk population for CVD. This project investigated 1) trends in prevalence of obesity for US WV and potential ethnic/ racial differences during 2000-2019, and 2) compared the latest rates between US WV and adult US civilian women. Methods: The national Veterans Affairs (VA) electronic health records were utilized to assess prevalence of obesity among US WV who visited a VA facility from 1/1/2000 to 12/31/2019. The diagnosis of obesity was based on International Classification of Disease (ICD) 9th and 10th version diagnostic codes. Results: The overall prevalence of obesity among WV increased from 26,548 (32.9%) to 386,708 (52.3%) during this period. While an increase in prevalence was observed in all races and ethnic cohorts, there was significant differences in such prevalences among the cohorts with rates highest among Blacks and American Indians. The latest overall rate for WV. 52.3% is significantly higher than the rate reported by Center for Disease Control in 2020 for civilian women, 42.1%. Conclusion: The obesity epidemic among US WV reaches highest rates ever recorded, is significantly higher than those reported for US civilian women, and reveals significant racial and ethnic differences.