Abstract: Neurofeedback is emerging as a psychophysiological treatment where self-regulation is achieved through online feed-back of neural states. Novel personalized medicine approaches are particularly important for the treatment of posttrau-matic stress disorder (PTSD), as symptom presentation of the disorder, as well as responses to treatment, are highly het-erogeneous. Learning to achieve control of specific neural substrates through neurofeedback has been shown to display therapeutic evidence in patients with a wide variety of psychiatric disorders, including PTSD. This article outlines the neural mechanisms underlying neurofeedback and examines converging evidence for the efficacy of neurofeedback as an adjunctive treatment for PTSD via both electroencephalography (EEG) and real-time functional magnetic resonance imaging (fMRI) modalities. Further, implications for the treatment of PTSD via neurofeedback in the military mem-ber and Veteran population is examined.