Abstract: This study investigated the relationships between psychological inflexibility, mindful self-care, and post-military reintegration among 208 U.S. military veterans from various service eras and branches. Recruited online through participatory research methods, veterans completed measures of psychological inflexibility (AFQ-Y), post-military reintegration (M-CARM), mindful self-care (MSCS), and psychological distress (CORE-10), among others. Regression and correlational analyses supported the hypotheses that psychological inflexibility would be negatively associated with post-military reintegration, while mindful self-care would be positively associated with post-military reintegration. Psychological inflexibility accounted for 36% of the variance in post-military reintegration, while mindful self-care and psychological distress accounted for 21% and 20%, respectively. This study provides preliminary support for targeting psychological inflexibility and mindful self-care as intervention strategies for post-military reintegration in U.S. veterans. This study highlights promising implications for clinical interventions to improve post-military reintegration through strengths-focused, whole-health approaches. Limitations and future research are discussed.