Abstract: Post-traumatic headache (PTH) is a common consequence of mild traumatic brain injury (mTBI), accounting for 55–60% of post-concussion syndrome cases. Veterans are at heightened risk due to frequent exposure to TBIs from blasts, falls, and crashes. Migraine-like PTH is a prominent subtype, often associated with post-traumatic stress disorder (PTSD). Current pharmacological treatments, including NSAIDs, triptans, and opioids, face limitations such as side effects, low efficacy, and poor compliance. This pilot feasibility study explored low-intensity focused ultrasound (LIFU) as a nonpharmacological treatment targeting the caudate nuclei, a brain region implicated in migraine pathophysiology. Two veterans with persistent migraine-like PTH underwent five daily LIFU sessions, with imaging and clinical evaluations conducted before, during, and after treatment. Patient B showed significant improvements in headache severity and functional impairment, with reductions in pain scores and PTSD symptoms. Patient A demonstrated modest benefits. Both participants reported a return of symptoms at a 1-month follow-up. LIFU was well tolerated, with no serious adverse effects or imaging abnormalities observed. This study highlights the feasibility of LIFU as a novel intervention for migraine-like PTH and underscores the need for further research with larger cohorts to assess its efficacy and long-term outcomes.