Abstract:Background: Posttraumatic stress disorder is prevalent among combat veterans in the United States. Mobile health-based interventions have the potential to provide non-invasive, discreet support for posttraumatic stress disorder patients. There is a need to understand the design requirements for an evidence-based, user-centered application for such interventions. Objective: This study sought to identify key expectations and requirements for the design of a veteran-centered, mobile health intervention for veterans with posttraumatic stress disorder. Methods: Participants (N = 50) with posttraumatic stress disorder were recruited from Project Hero biking events in five locations to participate in semi-structured interviews (n = 39), one focus group (n = 9), and one dyadic interview (n = 2). Qualitative thematic analysis was performed on transcripts by two coders with software facilitation (MAXQDA 12). Results: Thematic analysis of interviews identified key features including momentary assessment and intervention, periodic assessment and intervention features to help users recover in their long-term daily life, and connectivity. Conclusion: The information gathered and analyzed can be used to guide development and deployment of a mobile health application for aiding veterans with their daily struggles with posttraumatic stress disorder.