Abstract: The purpose of this study was to examine the association of rurality and veteran status on cardiovascular disease (CVD) risk in US adult females. A retrospective, cross-sectional cohort analysis was conducted utilizing data from the 2021–2023 National Survey on Drug Use and Health. The sample included female veterans and non-veterans (n=25,543). A multivariable logistic regression model was applied to the data to understand the association between the aforementioned variables, including an interaction term for rurality and veteran status. The interaction term showed that rural veteran females had a higher predicted rate of CVD risk than the other cohorts studied (aOR = 1.85, 95% CI = 1.14–3.00), even after adjusting for covariates. These findings highlight the relationship between veteran status and geographic location on CVD risk among females in the US.