Abstract: Background: Offspring of Vietnam veterans assert adverse health outcomes related to their fathers’ exposure to Agent Orange, but limited research exists on their postnatal health and lived experiences. Purpose: The purpose of this study was to explore the lived experiences of Vietnam veteran descendants and the impact of Agent Orange on their health. Methods: This qualitative study used an interpretive phenomenological design. Participants were selected via criterion-based sampling. Data were collected through semi-structured interviews and organized using NVivo 15. Discussion: Three themes were identified: attitudes toward Agent Orange (anger, frustration, and loss); chronic health conditions and their impacts; and transgenerational concerns about inheritability and future health. Conclusion: Findings underscore the need for epigenetic research into potential paternal transmission mechanisms. Nurses can promote research-informed policies that emphasize the health of veterans and military families while integrating educational strategies to address their unique needs.