• Author: Grant D. Huang
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Practice changing RCT design and rationale: Abbreviated MRI plus AFP vs. ultrasound plus AFP for HCC surveillance in cirrhosis (PREMIUM study)

Abstract: Abdominal ultrasound every 6 months with or without serum alpha-fetoprotein (AFP) is recommended for hepatocellular carcinoma (HCC) screening in patients with cirrhosis. …

Addressing challenges and barriers to rural Veteran participation in clinical research within the Veterans Affairs healthcare system

Abstract: The execution of clinical research in medical facilities that serve rural populations and/or that have lower care complexity levels has been proven to be challenging, as …

Development of a prediction model for 30-day COVID-19 hospitalization and death in a national cohort of Veterans Health Administration patients, March 2022-April 2023

Abstract: Objective: The epidemiology of COVID-19 has substantially changed since its emergence given the availability of effective vaccines, circulation of different viral …

Exoskeletal-assisted walking in Veterans with paralysis: a randomized clinical trial

Abstract: Importance: Robotic exoskeletons leverage technology that assists people with spinal cord injury (SCI) to walk. The efficacy of home and community exoskeletal use has not …

Identifying Veterans who benefit from nirmatrelvir-ritonavir: A target trial emulation

Abstract: Background: Nirmatrelvir-ritonavir is recommended for persons at risk for severe coronavirus disease 2019 (COVID-19) but remains underutilized. Information on which …

Correlates of suicidal behaviors and genetic risk among United States Veterans with schizophrenia or bipolar I disorder

Abstract: Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). …

Inviting Veterans into enrollment in Alzheimer's disease research centers (INVITE-ADRC): An NIA and VA-sponsored initiative to increase Veteran participation in aging and dementia research

Abstract: INTRODUCTION: Older military veterans often present with unique and complex risk factors for Alzheimer's disease (AD) and related dementias. Increasing veteran …

Correlates of risk for disinhibited behaviors in the million Veteran program cohort

Abstract: IMPORTANCE: Many psychiatric outcomes share a common etiologic pathway reflecting behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent …

Effectiveness of nirmatrelvir-ritonavir against the development of post-covid-19 conditions among U.S. veterans: a target trial emulation

Abstract: Background: COVID-19 has been linked to the development of many post-COVID-19 conditions (PCCs) after acute infection. Limited information is available on the …

Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans

Abstract: In randomized trials, prazosin, an α1-adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder (PTSD) in …

Veterans Individual Placement and Support Towards Advancing Recovery: Methods and Baseline Clinical Characteristics of a Multisite Study

Abstract: This article describes the methodology and the baseline characteristics of veterans with posttraumatic stress disorder (PTSD) enrolled in a multisite trial comparing …

A cross-cutting approach to enhancing clinical trial site success : The Department of Veterans Affairs' Network of Dedicated Enrollment Sites (NODES) model

Abstract: Background: Recruitment into clinical trials remains a key determinant to study completion and success. While various strategies have been proposed, it is unclear how …