• Author: Henry R. Kranzler
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Racial and ethnic disparities in buprenorphine retention and treatment outcome in a longitudinal cohort of U.S. Veterans with opioid use disorder

Abstract: Background: Despite the availability of efficacious opioid use disorder (OUD) medications (MOUD), there are racial and ethnic disparities in their use in the general …

Drug-gene interactions and clinical outcomes after vascular surgery in the Million Veteran Program

Abstract: IMPORTANCE: Pharmacogenetics can improve medication-related outcomes by optimizing efficacy and minimizing adverse effects. It is unknown whether the presence of …

A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi-ancestry population from the Million Veteran Program

Abstract: Background: Observational studies link moderate alcohol consumption to reduced risk of cardiometabolic diseases, including coronary heart disease (CHD) and type 2 …

Candidate genes from an FDA-approved algorithm fail to predict opioid use disorder risk in over 450,000 Veterans

Abstract: Importance: Recently, the Food and Drug Administration gave pre-marketing approval to algorithm based on its purported ability to identify genetic risk for opioid use …

A multi-ancestry genetic study of pain intensity in 598,339 Veterans

Abstract: Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes …

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Abstract: Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits, commonly co-occur in the general population. Single-trait genome-wide association …

Racial and Ethnic Bias in the Diagnosis of Alcohol Use Disorder in Veterans

Abstract: Studies show that racially and ethnically minoritized veterans have a higher prevalence of alcohol use disorder (AUD) than White veterans. The investigators examined …