• Author: John H. Krystal
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Developmental timing of index trauma exposure and accelerated epigenetic aging in United States military Veterans

Abstract: Trauma exposure has been linked to accelerated GrimAge, an epigenetic biomarker of premature morbidity and mortality. Building on this evidence, the present study …

Developmental timing of index trauma exposure and accelerated epigenetic aging in United States military Veterans

Abstract: Trauma exposure has been linked to accelerated GrimAge, an epigenetic biomarker of premature morbidity and mortality. Building on this evidence, the present study …

Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military Veterans

Abstract: Objectives: Major depressive disorder (MDD) is a leading cause of disability, and chronic inflammation is a contributing factor to its onset and progression. This study …

Problem opioid use among US military Veterans: Prevalence, correlates, and psychiatric characteristics

Abstract: OBJECTIVE: Problem opioid use (POU) is a serious public health crisis in the United States. However, little research has examined the prevalence, correlates, and …

Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military Veterans: Results from a 10-year, population-based, observational cohort study

Abstract: Background: Understanding the interplay between psychosocial factors and polygenic risk scores (PRS) may help elucidate the biopsychosocial etiology of high alcohol …

DSM-5 criterion-a-based trauma types in service members and veterans seeking treatment for posttraumatic stress disorder

Abstract: In posttraumatic stress disorder (PTSD), the assumption of the equipotentiality of traumas ignores potentially unique contexts and consequences of different traumas. …

Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden

Abstract:Background: Little is known about environmental factors that may influence associations between genetic liability to suicidality and suicidal behavior. Methods: This study …

Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic

Abstract: Importance: The COVID-19 pandemic has raised considerable concerns about increased risk for suicidal behavior among US military veterans, who already had elevated rates …

The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions

Abstract: United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health …

Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study

Abstract: The current study examined the nature and correlates of seven-year posttraumatic stress disorder (PTSD) symptom courses in a nationally representative, prospective …

The burden of alcohol use disorders in US military veterans: Results from the National Health and Resilience in Veterans Study

Abstract: Aims: To analyze data from a large, contemporary, nationally representative sample of US veterans to evaluate: (1) the prevalence of life-time alcohol use disorder (AUD) …