Abstract:Hereditary transthyretin amyloidosis is caused by pathogenic variants in the TTR gene, resulting in abnormal TTR (transthyretin) that deposits in organs. The c.424G>A …
Abstract:Objective: The prevalence of moderate to severe asymptomatic carotid stenosis (i.e., atherosclerotic narrowing of the extracranial carotid arteries) is generally ∼6% and …
Abstract: IMPORTANCE: Pharmacogenetics can improve medication-related outcomes by optimizing efficacy and minimizing adverse effects. It is unknown whether the presence of …
Abstract: Given the various roles of testosterone in men’s health, we conducted a multi-ancestral genetic analysis of total testosterone, free testosterone, SHBG, and …
Abstract: Purpose: This study introduces an integrated approach using structured and unstructured data from an electronic health record to identify and characterize patient …
Abstract: Introduction: Associations between cardiometabolic comorbidities and self-reported oral health (OH) are often underexplored in large biobank datasets. While these …
Abstract: Pharmacogenetic (PGx) testing before initiation of thiopurine treatment and CBC monitoring post-initiation helps avoid adverse events and ensure patient safety. This …