LGBTQ+ Veterans report greater subjective cognitive impairment and risk factors for Alzheimer's disease and related dementias

Abstract: Background: Alzheimer's disease and related dementias (ADRD) among the lesbian, gay, bisexual, transgender, queer, and/or additional marginalized sexual/gender identities …

Early outcomes of lecanemab for Alzheimer’s disease in the Veterans Health Administration

Abstract: Background/Objectives: While lecanemab (Leqembi) and several amyloid targeting therapies were approved for Alzheimer’s disease, questions remain on real-world …

Long-term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans

Abstract: INTRODUCTION: Alzheimer's disease and related dementias (ADRD) remain a leading cause of morbidity and mortality. Poor cardiorespiratory fitness (CRF) has been identified …

Machine learning-based risk scores are associated with conversion to dementia in Veterans

Abstract: Background: We previously developed ancestry-specific risk scores for undiagnosed Alzheimer's disease and related dementias (ADRD) in Black and White American (BA and WA) …

83. Supporting the safety of anti-amyloid monoclonal antibody therapy for early Alzheimer's disease in United States Veterans

Abstract: Introduction Aging United States Military Veterans are at an increased risk of developing dementia compared to the general population due to both military and …

Implementation of lecanemab for Alzheimer's disease within the Veterans Health Administration: Facilitators and barriers

Abstract: Background: Several amyloid targeting therapies have been approved for Alzheimer's disease (AD), including lecanemab (Leqembi). However, real-world implementation of …

Feasibility of identifying acute nontraumatic intracerebral hemorrhage events using diagnostic coding among Veterans with mild cognitive impairment or Alzheimer’s dementia

Abstract: Introduction: Based on manual review of clinical notes of using the International Classification of Diseases, Tenth Revision coding, we evaluated the feasibility and …

Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β(42:40) in Veterans

Abstract: BackgroundIdentifying biomarkers of Alzheimer's disease (AD) is critical for early diagnosis and AD risk assessment.ObjectiveWe examined the hypothesis that the plasma …

The Veterans Affairs Million Veteran Program, Alzheimer's disease, and genetics: Important steps forward but many steps still to go on the march to control dementia and Alzheimer's disease

Abstract: The VA Million Veteran Program (MVP) is a nationwide initiative that seeks to examine how genes influence health and behaviors in military veterans. An article by Merritt …

Subjective cognitive decline among older U.S. military Veterans: A 3-year, nationally representative, longitudinal study

Abstract: Subjective cognitive decline (SCD) is an early risk marker for dementia. This study examined the 3-year incidence and predictors of SCD using the Medical Outcomes Study …

Curation and validation of electronic medical record-based dementia diagnoses in the Veterans Affairs Million Veteran Program

Abstract: Background: The age distribution and diversity of the VA Million Veteran Program (MVP) cohort make it a valuable resource for studying the genetics of Alzheimer's disease …

Traumatic brain injury and genetic risk for Alzheimer's disease impact cerebrospinal fluid β-amyloid levels in Vietnam War Veterans

Abstract: Traumatic brain injuries (TBIs) may increase the risk for Alzheimer's disease (AD) and its neuropathological correlates, although the mechanisms of this relationship are …