Polygenic risk, Agent Orange exposure, and lymphoid neoplasms in the Veterans Affairs Million Veteran Program

Abstract: Importance: Agent Orange (AO), a toxic herbicide mixture contaminated with carcinogenic dioxin, was widely used during the Vietnam War. Although epidemiologic evidence …

Drug-gene interactions and clinical outcomes after vascular surgery in the Million Veteran Program

Abstract: IMPORTANCE: Pharmacogenetics can improve medication-related outcomes by optimizing efficacy and minimizing adverse effects. It is unknown whether the presence of …

Dietary cholesterol and myocardial infarction in the Million Veteran Program

Abstract: Background: Coronary artery disease is a leading cause of morbidity and mortality in the United States. Coronary artery disease can lead to major complications including …

Oral health, inflammation, and cardiometabolic factors in the VA Million Veteran Program

Abstract: Introduction: Associations between cardiometabolic comorbidities and self-reported oral health (OH) are often underexplored in large biobank datasets. While these …

Association of deployment characteristics and exposures with persistent ill health among 1990-1991 Gulf War Veterans in the VA Million Veteran Program

Abstract: Background: Veterans of the 1990-1991 Gulf War have experienced excess health problems, most prominently the multisymptom condition Gulf War illness (GWI). The Department …

Military and occupational exposures among Veterans in the Million Veteran Program by survey self-report: A descriptive study

Abstract: Objective: We aimed to characterise self-reported military and occupational exposures including Agent Orange, chemical/biological warfare agents, solvents, fuels, …

Cognitive symptoms in Veterans with migraine or traumatic brain injury: a Million Veteran Program study

Abstract: Objective: To examine the spectrum and severity of cognitive symptoms in veterans with migraine, traumatic brain injury (TBI), or both; and to evaluate the extent to …

Healthy lifestyle and prostate cancer risk in the Million Veteran Program

Abstract: Background: This study aims to assess the impact of healthy lifestyle on prostate cancer (PCa) risk in a diverse population. Methods: Data for 281,923 men from the …

Agent Orange exposure and prostate cancer risk in the million Veteran program

Abstract: Background: The US government considers veterans to have been exposed to Agent Orange if they served in Vietnam while the carcinogen was in use, and these veterans are …

A multi-ancestry genetic study of pain intensity in 598,339 Veterans

Abstract: Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes …

The Million Veteran Program 1990–1991 Gulf War Era survey: An evaluation of Veteran response, characteristics, and representativeness of the Gulf War Era Veteran population

Abstract: To address gaps in understanding the pathophysiology of Gulf War Illness (GWI), the VA Million Veteran Program (MVP) developed and implemented a survey to MVP enrollees …

Red meat intake and the risk of cardiovascular diseases: A prospective cohort study in the Million Veteran Program

Abstract: BACKGROUND: Red meat consumption was associated with increased risk of cardiovascular disease (CVD) in prospective cohort studies and a profile of biomarkers favoring …