Polygenic risk, Agent Orange exposure, and lymphoid neoplasms in the Veterans Affairs Million Veteran Program

Abstract: Importance: Agent Orange (AO), a toxic herbicide mixture contaminated with carcinogenic dioxin, was widely used during the Vietnam War. Although epidemiologic evidence …

Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military Veterans

Abstract: Objectives: Major depressive disorder (MDD) is a leading cause of disability, and chronic inflammation is a contributing factor to its onset and progression. This study …

Traumatic brain injury and genetic risk for Alzheimer's disease impact cerebrospinal fluid β-amyloid levels in Vietnam War Veterans

Abstract: Traumatic brain injuries (TBIs) may increase the risk for Alzheimer's disease (AD) and its neuropathological correlates, although the mechanisms of this relationship are …

Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk

Abstract: BACKGROUND: Suicide is a leading cause of death worldwide. Whereas some studies have suggested that a direct measure of common genetic liability for suicide attempts …

Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military Veterans: Results from a 10-year, population-based, observational cohort study

Abstract: Background: Understanding the interplay between psychosocial factors and polygenic risk scores (PRS) may help elucidate the biopsychosocial etiology of high alcohol …